Model structure of ferroportin and its docking with hepcidin reveals structural basis of iron homeostasis

Model structure of ferroportin and its docking with hepcidin reveals structural basis of iron homeostasis

May 26, 2012

Prasoon Kumar Thakur1, Vishrant Tyagi2, Faizan Ahmad2, Md. Imtaiyaz Hassan21Department of Computer Science, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.2Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ABSTRACT Hepcidin is a 25…

Comparative molecular docking approach on the series of antibacterial natural compounds for inhibition of NDM-1

Comparative molecular docking approach on the series of antibacterial natural compounds for inhibition of NDM-1

May 26, 2012

Prasoon Thakur1, Jitendra Kumar2, Divya Ray3, Md. Imtaiyaz Hassan41Department of computer science, Jamia Millia Islamia, New Delhi, India.2Beant College of Engineering &Technology, Gurdaspur, Punjab 143521, India.3Department of biotechnology, Post graduate government college, Chandigarh, Punjab, India.4Centre for Interdisciplinary Research in Basic Sciences, Jamia…

Identification of membrane associated drug targets in Borrelia burgdorferi ZS7- Subtractive genomics approach

Identification of membrane associated drug targets in Borrelia burgdorferi ZS7- Subtractive genomics approach

May 26, 2012

VijayakumariKarnataka State Women University, Jnanashakti campus, Athani Road, Bijapur, Karanataka, India. ABSTRACT Lyme disease is an infectious disease caused by a spirochete Borrelia burgdorferi ZS7. This spirochete is most often spread by ticks. Single antibiotic therapy is sufficient for containment of the early stage…

Structural basis of hepcidin binding to the α-2-Macroglobulin

Structural basis of hepcidin binding to the α-2-Macroglobulin

Prasoon Thakur1, Parvez Khan2, Faizan Ahmad2, Md. Imtaiyaz Hassan21Department of Computer Science, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.2Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ABSTRACT Hepcidin is a major regulator…

Mapping of natural antiviral leads against drug target network of HIV – A network pharmacology and system biology approach

Mapping of natural antiviral leads against drug target network of HIV – A network pharmacology and system biology approach

May 26, 2012

Amrendar Kumar, Abhilasha Singh, Swati Agarwal, Ramkishan AgarwalAmity Institute of Biotechnology, Amity University, Lucknow, India. ABSTRACT The specificity of drug targets is a great challenge in the pharma-proteomics field of virology. To eradicate such hurdle, here we have taken a novel step…

Three-dimensional quantitative structure-activity relationship analysis of a set of Pneumocystis crainii dihydrofolate reductase inhibitors using a pharmacophore generation approach

Three-dimensional quantitative structure-activity relationship analysis of a set of Pneumocystis crainii dihydrofolate reductase inhibitors using a pharmacophore generation approach

May 26, 2012

Ruchi Mishra, Ankita Agarwal, Sarvesh PaliwalDepartment of Pharmacy, Banasthali University, Rajasthan, India. ABSTRACT Pneumocystis carinii pneumonia (PCP) is one of the premier causes of morbidity and mortality in patients with acquired immunodeficiency syndrome (AIDS) and also affects patients with other immune disorders. 1 Trimetrexate (TMQ)…

Three-dimensional pharmacophore modelling of 4-quinolinyl and 9-acrydinylhydrazone analogues as potential inhibitors of Plasmodium falciparum

Three-dimensional pharmacophore modelling of 4-quinolinyl and 9-acrydinylhydrazone analogues as potential inhibitors of Plasmodium falciparum

May 26, 2012

Ankita Agarwal, Ruchi Mishra, Sarvesh PaliwalDepartment of Pharmacy, Banasthali University, Rajasthan, India. ABSTRACT Malaria is a mosquito-borne infectious disease of humans caused by eukaryotic protists of the genus Plasmodium. Four species of Plasmodium can infect and be transmitted by humans. Severe disease is largely caused…

Screening of natural antimutagenic chemotherapeutic compounds for the treatment of diabetes mellitus- An In silico pharmaco-chemical approach

Screening of natural antimutagenic chemotherapeutic compounds for the treatment of diabetes mellitus- An In silico pharmaco-chemical approach

May 26, 2012

Amrendar Kumar, Abhilasha Singh, Swati Agarwal, RamKishan Agarwal, RK TiwariAmity Institute of Biotechnology, Amity University, Lucknow campus, India. ABSTRACT The past two decades have seen an explosive increase in the number of people diagnosed with diabetes mellitus worldwide, which is found associated…

Design of indole based acetylcholinesterase inhibitors through molecular modeling, docking, and ADMET studies

Design of indole based acetylcholinesterase inhibitors through molecular modeling, docking, and ADMET studies

May 26, 2012

Nasimul Hoda, Jitendra KumarDepartment of chemistry, Faculty of Natural Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India. ABSTRACT Alzheimer’s disease (AD) the most common form of neurodegenerative senile dementia is associated with selective loss of cholinergic neurons and reduced levels…

Structure based In silico design of a novel class of potent and selective inhibitor of dihydropteroate synthase for anti-tubercular chemotherapy

Structure based In silico design of a novel class of potent and selective inhibitor of dihydropteroate synthase for anti-tubercular chemotherapy

May 26, 2012

Manoj Kumar, Gita Subba Rao, Sujata Sharma, TP Singh, Punit KaurDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi-110029, India. ABSTRACT Alarming increase in incidence of drug resistant TB and its synergy with HIV has led the WHO to declare…