Accessible surface area in the denatured proteins is the key factor for the perfect urea-methylamine compensation at 2:1 molar ratio under physiological conditions
May 26, 2012Safikur Rahman, Faizan AhmadCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India. ABSTRACT The potent denaturant, urea accumulates in large concentration in specific cells of various organisms. Urea disrupts protein structures, alters enzymes kinetic properties, interferes with…