Elucidating the specificity of non-heparin based conformational activators of antithrombin for factor Xa inhibition

Elucidating the specificity of non-heparin based conformational activators of antithrombin for factor Xa inhibition

May 26, 2012

Qudsia Rashid, Md. Asim Azhar, Asma Naseem, Md. Sazzad Khan, Poonam Singh, Mohamad Aman JairajpuriProtein Conformation and Enzymology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India. ABSTRACT An elevated prothrombotic state is a major risk factor for venous thromboembolism, atrial…

Role of helix B in serpin inhibition mechanism and polymerization

Role of helix B in serpin inhibition mechanism and polymerization

May 26, 2012

Poonam Singh, Monika Batra, Mohamad Aman JairajpuriProtein Conformation and Enzymology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India. ABSTRACT Serine protease inhibitors (Serpins) are prone to conformation defects, however little is known about the factors and mechanisms which promote its…

Glycerol-3 phosphate acyltransferase structural and active site identification through In silico approach

Glycerol-3 phosphate acyltransferase structural and active site identification through In silico approach

May 26, 2012

Namrata Misra, Prasanna Kumar Panda, Lala Bihari SuklaBioresources Engineering Department, Institute of Minerals and Materials Technology (formerly Regional Research lab), Council of Scientific and Industrial Research, Bhubaneswar-751 013, Orissa, India. ABSTRACT Glycerol-3 phosphate acyltransferase (GPAT) is an enzyme in the triacylglycerol (TAG)…

Structure, function, and diversity of human carbonic anhydrase isozymes

Structure, function, and diversity of human carbonic anhydrase isozymes

May 26, 2012

Bushra Zubair1, Danish Idrees2, Faizan Ahmad2, Md. Imtaiyaz Hassan21NICT, Sikkim Manipal university, India.2Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ABSTRACT Carbonic anhydrase (CA) is a Zn +2 -containing enzyme that catalyzes the reversible…

In silico structural and functional analysis of the P74 protein related to the (PDV) Polyhedra Derived Virus infection of BmNPV into the silkworm

In silico structural and functional analysis of the P74 protein related to the (PDV) Polyhedra Derived Virus infection of BmNPV into the silkworm

May 26, 2012

HM Kantharaj, SK Ashwath, S.M.H QadriBioinformatics Centre, Central Sericultural Research and Training Institute, Mysore, India. ABSTRACT The proteomic studies in general and prediction and structural elucidation of protein, in particular adapt an in silico approach. With the advent of functional genomics and…

Structure-function relationship of Mitogen Activated Protein kinase signal interacting kinase (Mnk1), a potent tumorigenic protein

Structure-function relationship of Mitogen Activated Protein kinase signal interacting kinase (Mnk1), a potent tumorigenic protein

May 26, 2012

Khalid Anwar, Faizan Ahmad, Md. Imtaiyaz HassanCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia (Central University), Jamia Nagar, New Delhi 110 025, India. ABSTRACT MAP (Mitogen Activated Protein) kinase-interacting serine/threonine-protein kinase 1 (Mknk1 or Mnk1) is an important intermediate member…

Insilico study of the A 2A R-D 2 R kinetics and revelation of residues Involved at the interfacial surface for heteromerization

Insilico study of the A 2A R-D 2 R kinetics and revelation of residues Involved at the interfacial surface for heteromerization

May 26, 2012

Amresh Prakash, Pratibha Mehta, LuthraMedicinal Chemistry Division, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, Mall Road, Delhi 110007, India. ABSTRACT The structural and dynamic information of A 2A R-D 2 R could provide a more complete understanding…

Structural features of lysosmal proteins: A structure based analysis to understand the mechanism of lysosomal storage disease

Structural features of lysosmal proteins: A structure based analysis to understand the mechanism of lysosomal storage disease

May 26, 2012

Huma Naz, Faizan Ahmad, Md. Imtaiyaz HassanCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ABSTRACT Lysosomal storage diseases are occurs due to inherited deficiencies in various enzymes involved in basic metabolic processes. These enzymes…

Structure based function prediction of putative conserved proteins from Candida dubliniensis

Structure based function prediction of putative conserved proteins from Candida dubliniensis

May 26, 2012

Munazzah Tasleem, Seemi Kalam, Faizan Ahmad, Md. Imtaiyaz HassanCentre for Interdisciplinary Research in Basic Sciences, Jamia Nagar, New Delhi 110025, India. ABSTRACT Candida dubliniensis genome contains 8 chromosomes, 6095 gene sequences, 5860 protein coding sequences. Out of these 5860 protein coding sequences…