Three-dimensional structure prediction of putative conserved proteins from R. rickettsiae: An approach to function annotation

Three-dimensional structure prediction of putative conserved proteins from R. rickettsiae: An approach to function annotation

May 26, 2012

Sobia Zaidi, Faizan Ahmad, Md. Imtaiyaz HassanCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi-110025, India. ABSTRACT Rickettsia is a genus of motile, gram negative and non spore forming highly pleomorphic bacteria having many virulent genes. Due to these…

In Silico analysis of flexible loop domain’s conformational changes affecting BH3 cleft of Bcl-2 protein

In Silico analysis of flexible loop domain’s conformational changes affecting BH3 cleft of Bcl-2 protein

May 26, 2012

Pawan Kumar Raghav, Yogesh Kumar Verma, Gurudutta U GangenahalliStem Cell and Gene Therapy Research Laboratory, Institute of Nuclear Medicine and Allied Sciences (INMAS), Lucknow Road, Timarpur, Delhi-110054, India. ABSTRACT Besides four Bcl-2 homology (BH1, BH2, BH3 and BH4) domains, the flexible loop…

Validation of Bhageerath-H: A homology ab-intio hybrid web server for protein tertiary structure prediction

Validation of Bhageerath-H: A homology ab-intio hybrid web server for protein tertiary structure prediction

May 26, 2012

Munazzah Tasleem1, B Jayaram21Department of Computer Sciences, Jamia Millia Islamia, Delhi, India.2Indian Institute of Technology, Delhi, India. ABSTRACT To assess the accuracy of Bhageerath_H and to suggest improvement in it so as to take it to perfection where it gives the best…

Predicting the stability of protein using its atomic coordinates in Protein Data Bank (PDB)

Predicting the stability of protein using its atomic coordinates in Protein Data Bank (PDB)

May 26, 2012

Syed Ausaf Ali, Asimul Islam, Faizan AhmadCenter for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India. ABSTRACT If protein stability is defined as Gibbs free energy change (∆GD°) associated with the denaturation equilibrium, native (N) conformation↔structureless denatured (D) conformation…

Protein modeling studies for antibacterial drug target

Protein modeling studies for antibacterial drug target

May 26, 2012

Anjana Ghelani1, Pravin Dudhagara2, Bhoomi Patel3, Rajesh Patel31Department of lifesciences, Hemchandracharya North Gujarat University, Patan; Shree Ramkrishna Institute of Computer Education and applied sciences, Surat, Gujarat, India.2Department of lifesciences, Hemchandracharya North Gujarat University, Patan; Department of Biotechnology, VeerNarmad South Gujarat University, Surat,…

Modeling of small molecule to hinder serine protease inhibitor polymerization

Modeling of small molecule to hinder serine protease inhibitor polymerization

May 26, 2012

Md. Sazzad Khan, Mohamad Aman JairajpuriProtein Conformation and Enzymology Lab, Department of Biosciences, Jamia Millia Islamia University, New-Delhi-110025, India. ABSTRACT Identifying the molecular basis of protein aggregation mechanism and devising its cure is an exciting area of protein chemistry. Serine Protease Inhibitor…

STAT6: An overview to its homology modeling

STAT6: An overview to its homology modeling

May 26, 2012

Shahzaib Ahmad1, Md. Imtaiyaz Hassan2, Andrew M Lynn31Department of Computer Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi-110025, India.2Center for interdisciplinary Research in basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi-110025, India3Schools of Computational and Integrative Science, JNU, New Delhi-110067, India…

Structure based prediction of stability for human β-glucronidase mutants

Structure based prediction of stability for human β-glucronidase mutants

Faez Iqbal Khan1, Md. Zubbair Malik1, Md. Imtaiyaz Hassan21Department of Computer Science, Jamia Millia Islamia, New Delhi, India.2Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ABSTRACT Mucopolysaccharidosis or Sly syndrome, caused by deficiency of…

Drug design In-silico approach for comparative study of various leads for a specific cancerous cell

Drug design In-silico approach for comparative study of various leads for a specific cancerous cell

May 26, 2012

Jawed Ahmed, Ruchika Bhat, Preetirupa SaikiaDepartment of Computer Science, Jamia Hamdard, New Delhi-110062, India. ABSTRACT Cancer is a deadly disease which is known to occur for various reasons. Some researches proved it to be a cause of mutations in genes, while other’s…