Structural fidelity in protein inhibitors of peptidases

Structural fidelity in protein inhibitors of peptidases

May 26, 2012

Lunminlal Kipgen, Sugandha Saxena, Kamal K AggarwalUniversity School of Biotechnology, Guru Gobind Singh Indraprastha University, Dwarka-16C, New Delhi, India. ABSTRACT The functional information of peptidase inhibitors reside within a few peptides at the reactive site. Reactive sites of serine, cysteine and carboxypeptidase…

Docking studies of two taxane diterpenoids (10,13-deacetyl-abeo-baccatin-Iv And 5-acetyl- 2-deacetoxydecinnamoyl-taxinine-0.29hydrate) with microtubule

Docking studies of two taxane diterpenoids (10,13-deacetyl-abeo-baccatin-Iv And 5-acetyl- 2-deacetoxydecinnamoyl-taxinine-0.29hydrate) with microtubule

May 26, 2012

Umesh Yadava, Hariom Gupta, M RoychoudhuryDepartment of Physics, DDU Gorakhpur University, Gorakhpur (U.P.), India. ABSTRACT The Himalayan yew (Taxus Wallichiana) is a tree or a large shrub growing on either sides of Himalayas from Afganistan to Burma1. The long and legendry history of the…

Protein-protein docking of serine proteinase of nematodes with plant proteinase inhibitors

Protein-protein docking of serine proteinase of nematodes with plant proteinase inhibitors

May 26, 2012

C.V.S. Siva Prasad, Saurabh Gupta, MD TiwariDepartment of Bioinformatics, Applied Science Division & IRCB, Indian Institute of Information Technology, Allahabad-21012, India. ABSTRACT Root-knot nematodes are plant-parasitic nematodes on horticultural and agricultural crops; they cause damage on root of the plant. Generally the…

Designing new leads for neuraminidase using Ab-initio approach

Designing new leads for neuraminidase using Ab-initio approach

May 26, 2012

Alka Shrivastava1, Mohd Nazir1, Chitra Gupta21Department of Computer Sciences, Jamia Millia Islamia University, Jamia Nagar, New Delhi-25, India.2Mascon Global Limited, 849, Udyog Vihar, Phase-V, Gurgaon, Haryana – 122016, India. ABSTRACT Influenza constitutes one of the most important upper respiratory tract infections regarding…

Molecular interaction studies of toxic proteins and neurotransmitters towards development of novel drugs for alzheimer disease

Molecular interaction studies of toxic proteins and neurotransmitters towards development of novel drugs for alzheimer disease

May 26, 2012

R Sathish Kumar, Murugesh Easwaran, C Nilavamudhan, P ShanmughavelDBT-Bioinformatics Center, Computational Biology lab, Bioinformatics Department, Bharathiar University, Coimbatore – 641046, Tamilnadu, India. ABSTRACT Amyloid beta, Presenilin, Apolipoprotein E and Acetylcholine structure−stability findings, emerges as an optimal target for alzheimer disease. The development…

In-silico inhibitor designing for HIV-1 integrase in Human Immunodeficiency Virus

In-silico inhibitor designing for HIV-1 integrase in Human Immunodeficiency Virus

May 26, 2012

Irin Sarah Jacob, Archana Singh, Sarika N Suryawanshi, Vikas GautamDepartment of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER) EPIP Campus, Industrial Area, Hajipur – 844102, Bihar, India. ABSTRACT Acquired immune deficiency syndrome (AIDS) is a disease of the human immune…

In-Silico inhibitor designing for Plasmodiumfalciparum aspartate aminotransferase (Pfaspat) in malaria

In-Silico inhibitor designing for Plasmodiumfalciparum aspartate aminotransferase (Pfaspat) in malaria

May 26, 2012

Archana Singh, Irin Sarah Jacob, Vikas Gautam, Sarika N SuryawanshiDepartment of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), EPIP Campus, Industrial Area, Hajipur – 844102, Bihar, India. ABSTRACT Malaria remains one of the most prevalent infectious parasitic diseases worldwide killing…

In-Silico Modeling and Inhibitor Designing through Fragment Based Drug Discovery (FBDD) Approach for Arylamine N-Acetyltransferase (NAT) in Mycobacterium tuberculosi

In-Silico Modeling and Inhibitor Designing through Fragment Based Drug Discovery (FBDD) Approach for Arylamine N-Acetyltransferase (NAT) in Mycobacterium tuberculosi

May 26, 2012

Vikas Gautam, Archana Singh, Irin Sarah Jacob, Sarika N SuryawanshiDepartment of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER) EPIP Campus, Industrial Area, Hajipur – 844102, Bihar, India. ABSTRACT Tuberculosis is one of the most prevalent infections of human beings and…

Carbohydrate ligand interactions with genotype variants of cholera toxin B

Carbohydrate ligand interactions with genotype variants of cholera toxin B

May 26, 2012

Sunil KumarInstitute of Life Sciences, Department of Biotechnology, Nalco Square, Bhubaneswar, India. ABSTRACT Vibrio cholerae produces cholera toxin (CT) that consists of two subunits, A and B, and is encoded by a filamentous phage CTXΦ. The A subunit carries enzymatic activity that ribosylates…

Receptor chemoprint based pharmacophore modeling and virtual screening approach to obtain the novel hits in search of dopamine receptor subtype selective and potent agonists

Receptor chemoprint based pharmacophore modeling and virtual screening approach to obtain the novel hits in search of dopamine receptor subtype selective and potent agonists

May 26, 2012

Amresh Prakash, Pranjul Mishra, Pratibha Mehta LuthraMedicinal Chemistry Division, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, Mall Road, Delhi 110007, India. ABSTRACT The ligand-based method has been very popular for a long time, however, the quality of…